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Brazilian Cochrane Center

General Information
[Background] [Objectives] [Suport] [Reports] [Contribution to IRCC] [Training]



The Brazilian Cochrane Center (BrCC) was opened in October 1996 and is located in the Clinical Trials and Meta-analysis Unit in the Federal University of São Paulo. The CCB collaborates with health services researchers, medical schools, consumers, governments and other interested parties across Brazil.

The aims of the Brazilian Cochrane Centre are to collaborate with others to build, maintain and disseminate a database of systematic, up-to-date reviews of randomised controlled trials of health care.



1. Relevant to Cochrane Collaboration Goal 1:

a) to contribute to the Cochrane Controlled Trials Register by searching Latin American sources for eligible reports, and provide English translations of the titles of RCTs published in Portuguese and Spanish.

b) to identify and assist people in Brazil and neighbouring countries who are willing to participate in collaborative review groups as reviewers or module editors.

c) to organise workshops and seminars to support and guide reviewers in Brazil and neighbouring countries.

2. Relevant to Cochrane Collaboration Goal 2:

a) to disseminate the findings of systematic reviews to health care agencies, policy makers, professional bodies, practitioners and consumers in Brazil.

b) to assist Brazilian health care agencies, policy makers, professional bodies and consumers to be aware of and harness the information contained in Cochrane reviews as they become available.

c) to promote research into the science of systematic reviews. Countries for which the Centre is the reference Cochrane centre Argentina, Chile, Colombia, Mexico.



Sources of funding support:

The Federal University of São Paulo and personal funds are currently the only sources of funding support for the Brazilian Cochrane Center.


The Centre is grateful for the encouragement and support it has received from many individuals, particularly, Helio Egydio Nogueira (rector of the Federal University of São Paulo), Adauto Castelo Filho (director of CEU UNIFESP) and Brian Haynes and Iain Chalmers (directors of the Canadian and UK Cochrane Centres, respectively).



Annual Report
Scheduled for September, 1997.

Strategic Plan
Currently being developed with Steering Committee

Other Publications

Atallah AN. Which anticonvulsant for women with eclampsia? Evidence from the Collaborative Eclampsia Trial. Lancet 1995; 345: 1455-63.

Atallah AN, Collins R, Peto R. Large and simple randomized clinical trial aspirin for prevention of low birth weight and perinatal mortality in Brazil. In EV Cosmi, GC Di Renzo, eds. Bologna, Italy: Hypertension in Pregnancy, 1991: 273-277.

Atallah AN. ECPPA: randomized trial of low-dose aspirin for the prevention of maternal and fetal complications in high-risk pregnant women. British Journal of Obstetrics and Gynaecology (In Press)

Atallah AN. The appraisal of medical scientific evidence. São Paulo Medical Journal. 1995:113; 887.

Atallah AN. The Eclampsia Trial, a model of international collaborative study with worldwide benefits. São Paulo Medical Journal. 1995:113; 927-928.

Atallah AN. Methodologies to assess moderate therapeutic effects. São Paulo Medical Journal. 1995:113; 967.

Atallah AN. Molecular Medicine and Clinical Epidemiology: New Era, New Choices. São Paulo Medical Journal. 1995:113; 1007-1008.

Atallah AN. The ways of the scientific medical universe. São Paulo Medical Journal. 1996:114; 1067.

Atallah AN. Clinical investigation needed. São Paulo Medical Journal. 1996:114; 1107.

Chaves AC, Seeman MV, Mari JJ, Maluf A. Schizophrenia: impact of positive symptoms on gender social role. Schizophrenia Research 1993;11:41-45.

Mari JJ, Streiner D. An overview of family interventions and relapse on schizophrenia: meta-analysis of research findings. Psychological Medicine 1994;24:565-578.

Almeida NM, Santana V, Mari JJ. Revisão dos estudos epidemioló gicos em saú de mental no Brasil: Primeira parte. Jornal Brasileiro de Psiquiatria, 1988;37:227-231.

Almeida NM, Santana V, Mari JJ. Revisão dos estudos epidemioló gicos em saú de mental no Brasil: Segunda parte. Jornal Brasileiro de Psiquiatria 1988;37:291-295.

Ferraz MB. An evidence based appraisal of management of nontophaceous interval gout. J Rheumatology (In press).

Ciconelli RM, Ferraz MB, Oliveira LM, Atra E. A randomized controlled trial to evaluate the combination therapy sulfasalazine and pulse of methylprednisolone in patients with rheumatoid arthritis. Brit J Rheumatology (In press).

Darmavam J, Ferraz MB, Muirden K, Tugwell P. Case study: World Health Organization - International League of Association for Rheumatology. Community Oriented Programme for the control of Rheumatic Diseases (WHO-ILAR-COPCORD). Int J Technol Assess Health Care (In press).


Contribution to International Register of Controlled Trials



(None so far)


Alvaro Atallah and Jair Mari have organised courses in 'Systematic Reviews and Meta-analysis':

At the International Congress of Clinical Epidemiology, São Paulo May 1995

For faculty leaders in medical education in São Paulo, in October 1995 and August 1996, with Karla Soares

At the Federal University of Ceara, Brazil, in September 1996, with Edina M. Koga da Silva

Since November, 1995, Alvaro Atallah has coordinated and produced a TV program for the São Paulo Medical Association, named "Evidence Based Medicine". These programmes are broadcast daily, twice a day, across the whole of Brazil and Mercosul, and have included programmes on "Clinical Trials", "Systematic Reviews" (with Karla Soares), and " The Cochrane Collaboration" (with Iain Chalmers).

Forthcoming training activities
A programme of training activities will be developed by May, 1997, with the participation and guidance of Alejandro Jadad, Canadian Cochrane Centre.

Training materials
Will be prepared in Portuguese and Spanish, in collaboration with the BIOMED2 Project.

Future events
Possible meeting of Latin American Contributors to the Cochrane Collaboration in October 1998.


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